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Metabolic Stress Hormone FGF21:From Physiology to Pharmacology

Steven Kliewer  David Mangelsdorf  
【摘要】:正Fibroblast growth factor 21 (FGF21) is an unusual member of the FGF family that can circulate in the blood as a hormone.In liver,FGF21 is induced by diverse nutritional stresses including alcohol,simple sugars and high fat/low carbohydrate"ketogenic"diets,which can all cause dehydration.FGF21 released into the blood stimulates thirst and suppresses further intake of alcohol and sugar.

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